Page 453 - Essential Haematology

Index / 439

chronic 310 chemical exposure 152 treatment protocols 164
prevention 304 clonal progression 155–6 viral infections 153–4, 170–1
blood transfusion 408 cytogenetic analysis 164 haematopoietic tissue tumours,
chronic pattern 306–7 cytotoxic drugs 172–3, 174–5, WHO classifi cation
graft-versus-leukaemia eff ect 310 176 427–9
granulocyte colony-stimulating diagnosis 163 haematopoietin receptor
factor (G-CSF) 5, 8, diagnostic methods 160–1, 162, superfamily 8
112 163 haematuria 45
aplastic anaemia 294 DNA microarray platforms haemochromatosis, genetic causes
clinical applications 112 160–1, 162 51
neutropenia management 120 drug-induced 152 haemoglobin 19–22
neutrophil recovery 113 drug treatments 172–3, 174–5, abnormalities 91
peripheral blood stem cell 176 function 21–2
collection 300 environmental infl uences 152 genetic disorders 89–107
stem cell transplantation 301 epigenetic alterations 158 DNA diagnosis 105–6, 107
granulocyte concentrates 410 Epstein–Barr virus 153–4 fetal blood sampling 106
granulocyte–macrophage colony- fever 169–70 prenatal diagnosis 105–6, 107
stimulating factor (GM- FISH 160, 161 switch from fetal to adult 90–1
CSF) 7, 8 fl ow cytometry 161, 163 synthesis 19–20, 89–91
granulocytes 8, 109, 110–11 fungal infections 171, 172 see also anaemia
benign disorders 116–17 general support therapy 167–71, haemoglobin A (Hb A) 19, 89
myelodysplasia 217 172 switch from fetal 90–1
phagocytic function 112 genetic abnormalities 155, haemoglobin C (Hb C) disease
granulopoiesis 111–12 157–8, 159, 160 104–5
control 112, 113 genetic markers 163–4 haemoglobin D (Hb D) disease
grey platelet syndrome 341 genetics 154–6 105
growth factor receptors 8, 9, 10 haemostatic support 168 haemoglobin E (Hb E) disease 105
growth factors 4, 5 immunohistology 163 haemoglobin F (Hb F) 19–20, 22,
granulopoiesis 112 incidence 151, 152 89
haemopoiesis control 9 infections 153–4 switch to adult 90–1
haemopoietic 6–8 prophylaxis/treatment haemoglobin H (Hb H) disease 92,
169–71, 172 94, 97
H inherited factors 151 haemoglobin Lepore 93, 98, 99
H substance 399, 400 karyotype analysis 160 haemoglobin M (Hb M) 21
H63D mutation 52 management 167–77 haemoglobin oxygen dissociation
haem neutropenia 169–70 curve 21–2
structure 20 nutritional support 169 anaemia 25
synthesis 20 pain management 169 haemoglobin S (Hb S) 22
defects 47 PCR 160, 164 combination with other genetic
haematological malignancies point mutations 157, 158 defects of haemoglobin
151–65 protozoal infections 154 104
aetiololgy 151–4 psychological support 168–9 haemoglobin S (Hb S)–thalassaemia
antibiotics 169, 170 radiation-induced 152 104
bacterial infections 154, reproductive issues 169 haemoglobin Sβthal 100
169–70 response to therapy monitoring haemoglobin Sβthal (Hb Sβthal) 99
blood product support 167–8 164 haemoglobin SC (Hb SC) 100
central venous catheter insertion specifi c therapies 172–3, 174–5, haemoglobin SC (Hb SC) disease
167 176 104