Page 456 - Essential Haematology

442 / Index

hyperferritinaemia, genetic causes immunocytes 109 infections
51 function 110 allogeneic stem cell
hyperglobulinaemia 342 immunodefi ciency 139–40 transplantation 307–10
hyperhaemolysis syndrome 408 classifi cation 139 blood transfusion 402–4, 408
hyperhomocysteinaemia 367 stem cell transplantation 302 growth factor production 112
hypersplenism 146 immunoglobulin(s) (Ig) 130–1 haematological changes 388–91
hypertension functions 130–1 haematological malignancies
polycythaemia vera 205 gene rearrangements 131–2 153–4
thrombocytopenia 415 heavy-chain genes 131–2 prophylaxis/treatment
hyperviscosity syndrome 284–6 HIV infection 391 169–71, 172
hypochromic anaemias 34–49 light-chain genes 131–2 haemolytic anaemia 85–6
autosomal recessive 46 monoclonal 273 haemolytic uraemic syndrome
diff erential diagnosis 48 multiple myeloma 276–7 338
laboratory diagnosis 46 preparations 411 haemopoietic malignancies 254,
see also iron defi ciency anaemia replacement in CLL 241 255
hyposplenism 146, 147, 148 somatic hypermutation of genes multiple myeloma 281
infection prevention 148 237, 239 prevention in hyposplenism
vaccination recommendations specifi c 412 148
148 structure 130, 131 purpura 332
hypothyroidism 388 immunoglobulin A (IgA) 130 thalassaemia major 96
hypoxia-inducible factors (HIF) 18 Henoch–Schönlein syndrome thrombocytopenia 337
332 see also bacterial infections; fungal
I immunoglobulin-free light chains, infections; named
IDH1 and IDH2 183 serum levels in multiple conditions; viral infections
idiopathic thrombocytopenic myeloma 276 infectious mononucleosis 135–9
purpura (ITP) immunoglobulin G (IgG) 130 clinical features 135–6
acute 336–7 warm autoimmune haemolytic diagnosis 137–8
chronic 334–6, 337 anaemia 82, 83 diff erential diagnosis 138–9
diagnosis 342–3 immunoglobulin M (IgM) 130 Epstein–Barr virus 135
pregnancy 415–16 antibodies 398–9, 404 haematological abnormalities
warm autoimmune haemolytic autoantibody 138 138
anaemia association 83 cold autoimmune haemolytic treatment 139
see also autoimmune anaemias 84 inferior vena cava fi lter 377
thrombocytopenic immunoglobulin superfamily infl ammation 369
purpura 13 integrins 13
imatinib, ALL 233 immunohistology 163, 164 interferon α (IFN-α)
imatinib, CML 195–6, 197, 198 immunosuppression CML 198
resistance 198, 199 autoimmune thrombocytopenic essential thrombocythaemia 210
response to therapy 196, 197, purpura 336 polycythaemia vera 207
198 CLL 236 interferon γ (IFN-γ) 8
immobility, venous stasis 368 lymphopenia 139 interleukin 1 (IL-1) 392
immune haemolytic anaemias, reduction for post-transplant interleukin 3 (IL-3) 7, 8
drug-induced 84–5 lymphoproliferative intermittent compression devices
immune paresis, multiple myeloma diseases 312 377
276–7 warm autoimmune haemolytic international normalized ratio
immune response 133, 134, 135 anaemia 84 (INR) 375, 377
immune thrombocytopenia, CLL indirect antiglobulin test (DAT) interphase of cell cycle 10–11
237 404, 405 interstitial pneumonitis 309–10