Page 458 - Essential Haematology

444 / Index

leucodepletion 409 lymphocytosis 135–9 macrophage(s)
leucoerythroblastic reaction 118 causes 137 antigen presentation 114
leukaemia chronic lymphoid leukaemias nitric oxide 320
classifi cation 179 235 red cell destruction 74, 144
cytogenetic analysis 179 CLL 236 macrophage colony-stimulating
diagnosis of acute 179, 180 non-Hodgkin lymphoma 242 factor (M-CSF) 8, 10
incidence 151, 152 pleomorphic atypical 137–8 macrophage-derived sarcomas
lymphoma relationship 256 viral infections 390 270
molecular analysis 179 lymphoid neoplasms, precursor 428 major histocompatibility complex
see also named acute and chronic lymphoid organs (MHC) 303
leukaemias primary 127, 128 see also human leukocyte antigens
leukaemoid reaction 117, 382 secondary 127, 128, 135, 136 (HLA)
bacterial infections 388, 390 lymphoid tissue tumours, WHO malabsorption
Lewis antibodies 402 classifi cation 427–9 iron defi ciency 41, 42
livedo reticularis, antiphospholipid lymphoma 246 megaloblastic anaemia 65–6
syndrome 370 autologous stem cell vitamin B 12 64
liver/liver disease 355 transplantation 303 malaria
acute pattern graft-versus-host classifi cation 254–5 anaemia of chronic disorders 391
disease 306 genetic abnormalities 155 blood transfusion 403, 404
fetal haemopoiesis 2 HIV infection 154 Burkitt lymphoma association
haematological changes 387–8 leukaemia relationship 256 154, 268
iron overload 51, 52, 53, 54, 55 mature B-cell neoplasms 254–5 DARC 119
non-Hodgkin lymphoma 257 mature T-cell neoplasms 254–5 haematological changes 391,
sickle cell anaemia 102 red cell aplasia 294 393
thalassaemia major 95 see also named lymphoma diseases haemolytic anaemia 86
thrombocytopenia 355, 388 lymphopenia 139 splenectomy 148
veno-occlusive disease 310 lymphoplasmacytoid lymphoma thrombocytopenia 391
liver transplantation, haemophilia A 261–2, 265 malignancy
348 treatment 265 anaemia 382, 384
loiasis 391, 395 lymphoproliferative disorders, post- coagulation abnormalities
Luebering–Rapaport shunt 22, 23 transplant 312, 429 382–3, 384, 385
lupus anticoagulant 359–60, 369 lyphoid tissue, spleen 143, 144 folate defi ciency 71
lymph nodes 135, 136 lysosomal storage diseases 122–3, haematological changes 382–3,
lymphadenopathy 124, 125 384, 385
autoimmunoblastic 270 lysosomes 13, 115 HIV infection 391
Burkitt lymphoma 268, 269 platelet abnormalities 382–3,
causes 140 M 384, 385
diff erential diagnosis 140–1 M phase of cell cycle 10 polycythaemia 382
follicular lymphoma 266 macrocytes venous thrombosis 368, 383,
Hodgkin lymphoma 246 megaloblastic anaemia 67, 72 385
investigations 140–1 shape 72 white cell changes 382, 384
non-Hodgkin lymphoma 256 macrocytic anaemia 27, 59 see also named diseases and
lymphoblastic lymphoma 225, 269 diff erential diagnosis 72 tumours
lymphocytes 109–10, 127, 128, laboratory features 72 MALT lymphoma see mucosa-
129–30 non-megaloblastic 71–2 associated lymphoid
circulation 130 see also megaloblastic anaemia tissue (MALT) lymphoma
migration in spleen 143 macrocytosis, folate/vitamin B 12 mantle cell lymphoma 258, 259,
lymphocytic lymphoma 261 defi ciency 67 267