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32 MITOGUAZONE 691

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PROPRIÉTÉS PHARMACOLOGIQUES
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FREI REICH E.J. et al., methylglyoxal bis(guanylhydrazone) a new agent active against
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WILLIAMS-ASHMAN H.G., SEIDENFELD J., Aspects of the biochemical pharmacology
of methylglyoxal bis(guanylhydrazone), Biochem. Pharmacol., 1986, 35, 1217-1225.
DESIDERIO M.A. et al., lnvolvment of ornithine decarboxylase and polyamines in gluco-
coticoid-induced apoptosis in rat thymocytes, Cel/ Growth Different, 1995, 6, 505-513.
HARADA J, SUGIMOTO M., Polyamines prevent apopoptic cell death in cultured cere-
bellar granule neurons, Brain Res., 1997, 753, 251-259.
REDMAN C. et al., lnvolvment of polyamines in selenomethionine indiced apoptosis and
mitotic alterations in human tumor cells, Carcinogenesis, 1997, 18, 1195-1202.
JOHNSON T.D. et al., K-induced dilations ? in rat cerebral arteriesw are blocked by
MGBG, a polyamine analogue, J. Cereb. Blood Flow and Metab., 1997, 17, S283.
TAKAJI S., et al., Growth inhibition of he/icobacterpy/ori by a polyamine synthesis inhi-
bitor, methylglyoxal bis(cyclopentylamidinohydrazone), Lett. Appl. Microbiol., 1997,
25, 177-180.
MITCHELL B.A. et al., QacA multidrug efflux pump from Staphy/ococcus aureus : com-
parative analysis of resistance to diamidines, biguanidines and guanylhydrazones,
Antimicrob. Agents and Chemother., 1998, 42, 475-477.
DAVIDSON K. et al, Mitoguazone induces apoptose via a p53-independent mechanism,
Anti-Cancer drugs, 1998, 9, 635-640.
TONINELLO A. et al., The affects of methylglyoxal-bis(guanylhydrazone) on spermine
binding and transport in liver mitochondria, Biochem. Pharmacol., 1999, 58, 1899-
1906.
RILLEMA J.A. et al., Prolactin stimulation of iodine uptake and incorporation into protein
is polyamine-dependent in mouse mammary gland explants, Proc. Soc. Exp. Bio/.
Med., 2000, 224, 41-44.

RELATIONS STRUCTURE-ACTIVITÉ
PGBG
ELO H. et al., Biochemical and chemical characterization of phenylglyoxal bis(guanylhy-
drazone), an aromatic analogue of mitoguazone, AnticancerDrug Res., 1996, 11, 493-
508.
SANTA MARIA A. et al., In vitro cytotoxicity of guanylhydrazones (MGBG and PGBG) on
cultured chinese Hamsterovary cells, Meth. Find. Clin. Pharmacol., 1997, 19, 521-525.
DEGBG
YUAN Q. et al., Putrescine does not support the migration and growth of IEC-6 cells,
Am. J. Gastrointest. Liver Physiol., 2000, 278, G49-56.