Page 811 - Traité de chimie thérapeutique 6 Médicaments antitumoraux

39. AGENTS RADIO ET CHIMIOSENSJBJUSANTS 769

}
s
(r"- " P A çr PAH
~---
0 +
OH OH
benzoquinone 22
ou
naphtoquinone
0
•- hypoxie q~
1-
Ml _

o ± + PAH
OH OH
benzoquinone
2-substîtuée lactone 23
HZ
OH Z (\
< A
c + PAH
N
~
s» OH "'
sel d'imonlum 24
lndoloquinone
Figure 10 : Prodrogues utilisant les quinones
BIBLIOGRAPHIE

ARTICLES GÉNÉRAUX
BROWN J.M., The hypoxie cell : a target for selective cancer therapy (18th B.F. CAIN
memorial award lecture), Cancerresearch, 1999, 59, 5863-5870.
BROWN J.M. Hypoxie cytotoxic agents : a new approach to cancer chemotherapy, Drug
Resistance updates, 2000, 3, 7-13.
JAFFAR M. et al., Bioreductive and gene therapy approaches to hypoxie diseases,
Advanc. Drug Delivery Rev., 2001, 53, 217-218.
RAFSTAD E.K. eta/., Hypoxla promotes lymph node metastasis in human melanoma
xenografts by up-regulating the urokinase-type plasminogen activator receptor, Can-
cer Res., 2002, 62, 1847-1853.
QUINONES
PATTERSON L.H., McKEOWN S.R., AQ4N : a new approach to hypoxla- activated can-
cer chemotherapy, Br. J. Cancer, 2000, 83, 1589-1593.