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772                               APPROCHES THÉRA PEUTIQUES DIVERSES

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               dyl)porphyrins, porphyrin-N-oxides and a tirapazamine-porphyrin conjugate, Can.
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             • Utilisations
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              - Prodrogues
              SYKES B.M. et al., N-substituted 2-(2,6-dinitrophenylamino)propanamides: navel pro-
               drugs that release a primary amine via nitroreduction and intramolecular cyclisation,
               J. Med. Chem., 1999, 42, 346-355.
              - GD-tex
              YOUNG S.W. et al., gadolinium(lll) texaphyrin : a tumor selective radiation sensitizer that
                is detectable by MRI, Proc. Nat/. Acad. Sei. USA, 1996, 93, 6610-6615.
              ROSENTHAL D.I. et al., A phase I single-dose trial of gadolinium texaphyrin (Gd-Tex), a
                tumor selective radiation sensitizer detectable by magnetic resonance imaging, Clin.
                Cancer Res., 2000, 5, 739-745.
              BERNHARD E.J. et al., Re-evaluating gadolinium(III) texaphyrin as a radiosensitizing
                agent, Cancer Res., 2000, 60, 86-91.
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