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770 APPROCHES THERAPEUTIQUES DIVERSES

LOADMAN P.M. et al., A preclinical pharmacokinetic study of the bioreductive drug
AQ4N, Drug Metabol. and Disp., 2001, 29, 422-426.
ABOU-ZEID N. et al., Novel regioisomeric napthoquinones as bioreductively-activated
cytotoxins, Proceedings of the American Association for Cancer Research, Miami-
Beach, Oct-Nov 2001, # 371.

DÉRIVÉS NITRÉS
FIRESTONE A. et al., Nitroheterocycle reduction as a paradigm for intramolecular cata-
lysis of drug delivery to hypoxie cells, J. Med. Chem., 1991, 34, 2933-2935.
OYA N. et al., Optical isomers of a new 2-nitroimidazole nucleoside analog (PR-350
series): radiosensitization efficiency and toxicity, /nt. J. Radiation Oncology Bio/.
Phys., 1995, 33, 119-127.
SYKES B.M. et al., N-substituted 2-(2,6-dinitrophenylamino)propanamides : novel pro-
drugs that release a primary amine via nitroreduction and intramolecular cyclisation,
J. Med. Chem., 1999, 42, 346-355
WATANABE M. et al., Effects of PR-350, a newly developed radiosensitizer, on dihydro-
pyrimidine dehydrogenase activity and 5-fluorouracil pharmacokinetics, Cancer Che-
mother. Pharmacol., 2001, 47, 250-254.

TIRAPAZAMINE
• Voie d'accès, physicochimie
LEY K. et al., Antimicrobial 3-amino-1,2,4-benzotriazine 1,4-dioxyde, Brevet allemand,
2 204 574, 1974, Chem. abstr., 1973, 79, 115636k.
SENG F. et al., Antimicrobial (1,4-dioxo-1,2,4-benzotriazin-3-yl)-ureas, Brevet allemand,
2 255 946, 1974, Chem. abstr., 1974, 81, 63690t.
SENG F. et al., Antimicrobial 3-amino-1,2-4-benzotriazine, Brevet allemand, 2 255 947,
1972, Chem. abstr., 1974, 81, 63687x.
SENG F. et al., Microbicidal 3-amino-1,2,4-benzotriazine, Brevet allemand, 2 255 825,
1974, Chem. abstr., 1974, 81, 105578v.
ROBBINS R.F., SCHOFIELD K., Polyazablcyclic compounds. Part Il. Further derivatives
of benzo-1:2:4-triazine, J. Chem. Soc., 1957, 3186-3194.
MASON J.C., TENNANT G., Heterocyclic N-oxides. Part VI. synthesis and nuclear
magnetic resonance of 3-aminobenzo-1,2,4- triazines and their mono and di-N-oxi-
des, J. Chem. Soc. B, 1970, 911-916.
LEY K., SENG F., Synthesis unterVerwendung von Benzofuroxan, Synthesis, 1975, 415-
422., Angewandte int. ed., 1972, 11, 1009-1011.
• Pharmacocinétique
HOGAN B.L. et al., On-line coupling on in vivo microdialysis sampling with capillary elec-
trophoresis, Anal. Chem., 1994, 66, 596-602.
SENAN S. et al., Phase I and pharmacokinetic study of tirapazamine (SR 4233) adminis-
trfed every three weeks, Clin. Cancer. Res., 1997, 31-38.
McLAUGHLIN L. et al., Microdialysis with the microbore HPLC for the determination of
tirapazamine and its reduced metabolites in rats, Analyst, 2000, 25, 105-110.